U-BIOPRED stands for Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes. This is the technical name for the 5-year European-wide project (2010-2014), which aims:

  • to understand more about severe asthma
  • to determine how it differs from person to person
  • to uncover new information and ideas that could lead to the creation of effective new treatments

The Ubiopred sample collection consists of twenty different sample types (see below) from participants with severe asthma that are >18 years of age. Control participants with mild to moderate asthma defined as being well controlled or partially controlled according to GINA guidelines, and non asthmatic non smoking healthy adult controls are gender and age matched with the severe asthma participants. Participants are recruited at study centres across europe.

Collection commenced: 2012 (completed 2014)

If you would like further information about this sample collection please contact us.

Study Centres

  • Amsterdam (University of Amsterdam)
  • Southampton (Southampton General Hospital)
  • Manchester (Wythenshawe Hospital)
  • Imperial (Royal Brompton Hospital)
  • Catania (Agostino Gemelli University)
  • Copenhagen (The Danish Pediatric Asthma Center, Copenhagen University Hospital)
  • Stockholm (Karolinska University Hospital)
  • Krakow (Szpital University Hospital)
  • Bern (INSELSPITAL Universitätsspital)
  • Budapest (Semmelweis University)
  • France (North Hospital, Marseille)
  • Hannover (Fraunhofer Institute for Toxicology and Experimental Medicine)
  • Umea (Norrlands University)
  • Rome (Policlinico Universitario)
  • Nottingham (Nottingham City Hospital)
  • Bergen (Haukeland University Hospital)

Sample types

  • Sputum bacteriology
  • Sputum supernatant
  • Sputum cell pellet (proteomics)
  • Sputum cell pellet (transcriptomics)
  • Serum
  • Plasma
  • RNA blood
  • EDTA blood
  • Urine
  • Bronchial brushings
  • Nasal brushings
  • RNA Later Biopsy
  • GMA embedded biopsy
  • Paraffin embedded biopsy
  • Snap frozen biopsy
  • Throat swab bacterial