Epidemiological Studies in Atherosclerotic Renovascular Disease (ARVD)

We have an established portfolio of research into atherosclerotic renovascular disease (ARVD). We currently have a database containing complete data sets for >850 patients and this underpins research into the epidemiology and outcomes of this high-risk patient group. Particular interests include:

• Our work has helped clarify the pathogenesis of renal dysfunction in ARVD
• We are the first group to have systematically studied the heart in ARVD. Our group are the organisers of the Cardiac sub-study of the largest ever RCT (randomised controlled trial) in ARVD: ASTRAL (Angioplasty and STent for Renal Artery Lesions)
• We have shown that proteinuria predicts renal functional outcome in ARVD
• Genetic studies investigating factors related to renal functional and mortality outcome are planned for this cohort
• We have a novel technique to assess renal perfusion with MR; this incorporates novel methodology and provides a major advance in renal imaging. We have developed a technique to accurately measure GFR (glomerular filtration rate) during an MR scan
• Our latest work involving analysis of renal structure in relation to function has provided a method that can predict renal functional outcome after renal angioplasty, which has not hitherto been possible

Key Manchester Researchers:

• Tina Chrysochou
• Ala Eldeen Shurrab
• David Buckley (Imaging Science, Manchester University)
• Nick Chalmers (MRI)
• Philip Kalra