The immunoblotting results above show cross-reactivity between Bet v 1 and a homologue in strawberry. Bet v 1 fully inhibits IgE binding to the strawberry homologue but strawberry does not fully inhibit binding of IgE to Bet v 1 (Karlsson et al. 2004) . Birch pollen is likely to be the primary sensitising agent. Mal d 1 also inhibits IgE binding and allergens from other Rosaceae fruits such as cherry Pru av 1 are also likely to cross-react.
Karamloo et al. (2001)  found that strawberry extract could inhibit binding of IgE from pear allergic patients to Pyr c 5 by 50%, suggesting that a strawberry phenylcoumaran benzylic ether reductase is a potential croos-reactive allergen.
Rodriguez et al. (2000)  note that 13/22 patients were pollen allergic. Since birch pollen allergy is less common to Bet v 1 in Spain than Northern Europe, it is possible that Bet v 1 independent IgE cross-reactivity of strawberry with peach exists as seen between peach and apple.
Kim and Hussain (1999)  report that 1/137 latex allergic patients was allergic to strawberry.
Wadee et al. (1990)  describes a patient with serum IgE showing cross-reactivity between cling peaches, strawberries, mandarins, guavas and bananas as demonstrated by pre-adsorbsion and ELISA.
Karlsson et al. (2004)  report that both strawberry protein extract and Bet v 1 cause basophil degranulation in patient's sera, suggesting that the allergens are clinically relevant.
Contact dermatitis due to strawberry has been described (Taylor et al, 1996 ; Weltfriend et al. 1995 ;Grattan & Harman, 1985 )