Tissue metabolism in the development and progression of breast cancer
The primary research goals are to delineate breast epithelial cell behaviour within its tissue context and to determine how the breakdown of normal cell interactions with the local stromal environment results in perturbed tissue organisation, proliferation, and survival of cancer cells.
This information aims to predict patients that will develop breast cancer and identify those who will become resistant to therapy. It also aims to identify new therapeutic targets for both the prevention and treatment of the disease.
The importance of such metabolic phenotypes has led Professor Lisanti to launch the Manchester Centre for Cellular Metabolism (MCCM) which is another Centre within the Institute of Cancer Sciences which cuts across all Faculties.