Breast cancer risk prediction and prevention

The Nightingale Centre and the Genesis Prevention Centre are situated on the University Hospital of South Manchester (UHSM) complex in Wythenshawe. It provides a base for one of the most ambitious breast cancer prevention research programmes in Europe. 

Along with Manchester Breast Centre (MBC) collaborators the team in the Centre for Women's Cancer are looking at prevention and risk in a number of different ways and are particularly interested in biomarkers as new determinants of risk, which may be used alongside current methods of risk prediction, development of screening, and pharmacological and lifestyle measurements to prevent breast cancer. 

This has led to the development of Family History and Prevention Clinics (FHC clinics); where over 8,000 women are followed.  Furthermore, a programme for determining risk in 60,000 women in the National Health Service Breast Screening Programme has been established (Principal Investigator Professor Anthony Howell). Novel BC chemo-preventative agents are also in development with grant funding secured to conduct the first trial of an antiprogestin in the breast cancer prevention setting (Chief Investigator Dr Sacha Howell).

Principal investigators