The Centre comprises several major groups whose key strengths are multidisciplinary working and critical mass. The scope of the research encompasses laboratory based investigation, translational research and early and late phase clinical trials.
Breast Cancer Research Group (BCRG)
Four key research themes are being pursued by the Women’s Cancer Centre BCRG principal investigators:
- Tissue metabolism in the development and progression of breast cancer
(Professor Michael Lisanti and Dr Federica Sotgia)
- Stem cell hierarchy in the normal breast and breast cancer
(Dr Robert Clarke and Dr Gillian Farnie)
- Translational breast cancer treatment trials
(Dr Sacha Howell, Dr Anne Armstrong, Miss Cliona Kirwan and Professor Nigel Bundred)
- Breast cancer risk prediction and prevention
(Professor Anthony Howell and Dr Sacha Howell)
Significant overlap exists between the investigators within themes but also externally to other collaborations both within the Manchester Breast Centre and more widely with our national and international collaborators
Gynaecological Cancers Research Group
The Centre for Women’s Cancer's gynaecological cancers portfolio encompasses dynamic research across all three major cancer sites: cervix, endometrium and ovary.
Principal investigators lead internationally-recognised programmes focussing on the cross-cutting themes of early diagnosis and prevention, tumour biology and heterogeneity as well as providing leadership for clinical trials from early phase and translational studies through to large international phase III randomised trials. There are substantial interactions and cross-fertilisation of ideas across tumour sites and with external collaborators with the strategic objective of translating novel biological insights into clinically meaningful improvements in the care of women with gynaecological malignancies.
- HPV-associated malignancies
(Professor Henry Kitchener, Dr Ian Hampson, Dr Lynne Hampson)
- Endometrial cancer and obesity
(Dr Emma Crosbie, Dr Andrew Renehan)
- Ovarian cancer: biology, early detection and clinical trials
(Professor Gordon Jayson, Professor Richard Edmondson, Dr Andrew Clamp, Dr Bobby Graham)