Top ten research questions for endometrial cancer (EC) that emerged from broad-based engagement
1. Is it possible to develop a personalised score which reflects a woman’s individual risk of developing EC?
2. Which women with abnormal vaginal bleeding should be referred for specialist review?
3. What are the most effective treatments currently available for advanced EC and what key molecular pathways should be targeted when developing new treatments?
4. Can we predict which women will benefit from adjuvant chemotherapy or radiotherapy and avoid ineffective treatments?
5. Are blood tests, including markers like CA125, useful in predicting duration of survivorship and/or recurrent disease?
6. What ways of raising public awareness about EC are the most effective and cost effective?
7. What are the psychological issues surrounding diagnosis and treatment of EC and what interventions might be helpful?
8. What are the underlying causes of different types of EC and how do they develop?
9. Can we predict at the time of diagnosis which endometrial cancers and precancerous lesions will respond to hormone treatments?
10. Do changes in lifestyle, including weight loss, reduce the risk of recurrence and improve survival in women who have been treated for EC?
For more information (the final 30 questions and the available evidence for all submitted questions) please see http://www.jla.nihr.ac.uk/priority-setting-partnerships/womb-cancer/