Our research includes translational studies of immune modulation in ischaemic stroke, primary intracerebral haemorrhage and subarachnoid haemorrhage, studies in stroke rehabilitation and implementation into clinical practice.
The Vascular Research theme uses multi-disciplinary approaches to advance our understanding of the mechanisms underlying small and large artery function in health and disease. This understanding is critical because alterations in arterial function are responsible for promoting vascular disease, such as hypertension and atherosclerosis, which if untreated lead to cardiovascular complications including ischaemic heart disease and heart failure.
Our investigations include
- Small artery contractility and remodeling
- The signaling pathways that regulate artery and smooth muscle function, and
- The mechanisms that underlie, angiogenesis, vascular calcification and atherosclerosis.
We study these processes using in vivo, ex vivo and in vitro models and translate our findings to human disease through close interactions with clinical researchers within the theme. Our research encompasses: