Publications: Pathogenesis of IVD degeneration

  • 2013

    Article

    • Gilbert, H. T. J., Nagra, N. S., Freemont, A. J., Millward-Sadler, S. J., & Hoyland, J. A. (2013). Integrin - Dependent Mechanotransduction in Mechanically Stimulated Human Annulus Fibrosus Cells: Evidence for an Alternative Mechanotransduction Pathway Operating with Degeneration. PLoS ONE, 8(9), [e72994]. DOI: 10.1371/journal.pone.0072994. Publication link: da916dee-2e6a-486b-96ca-6fefcc3cbfb5 | PubMed:24039840
  • 2012

    Article

  • 2011

    Article

    • Gilbert, H. T. J., Hoyland, J. A., Freemont, A. J., & Millward-Sadler, S. J. (2011). The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: An altered mechanotransduction pathway with degeneration. Arthritis Research and Therapy, 13(1), [R8]. DOI: 10.1186/ar3229. Publication link: f31a77fd-1874-46b1-a337-415db40bac11 | PubMed:21276216
  • 2010

    Article

    • Gilbert, H. T. J., Hoyland, J. A., & Millward-Sadler, S. J. (2010). The response of human anulus fibrosus cells to cyclic tensile strain is frequency-dependent and altered with disc degeneration. Arthritis and Rheumatism, 62(11), 3385-3394. DOI: 10.1002/art.27643. Publication link: 3fa1643e-4e2d-4243-bea3-b6187f612aa7 | PubMed:20617521
    • Minogue, B. M., Richardson, S. M., Zeef, L. A. H., Freemont, A. J., & Hoyland, J. A. (2010). Transcriptional profiling of bovine intervertebral disc cells: Implications for identification of normal and degenerate human intervertebral disc cell phenotypes. Arthritis Research and Therapy, 12(1), [R22]. DOI: 10.1186/ar2929. Publication link: a46c00ed-9e74-4820-8d12-ae1b224598e5 | PubMed:20149220
    • Tolofari, S. K., Richardson, S. M., Freemont, A. J., & Hoyland, J. A. (2010). Expression of semaphorin 3A and its receptors in the human intervertebral disc: Potential role in regulating neural ingrowth in the degenerate intervertebral disc. Arthritis Research and Therapy, 12(1), [R1]. DOI: 10.1186/ar2898. Publication link: 942638b7-76cd-4a7a-a73f-e96b18941132 | PubMed:20051117
  • 2009

    Article

    • Le Maitre, C. L., Frain, J., Millward-Sadler, J., Fotheringham, A. P., Freemont, A. J., & Hoyland, J. A. (2009). Altered integrin mechanotransduction in human nucleus pulposus cells derived from degenerated discs. Arthritis and Rheumatism, 60(2), 460-469. DOI: 10.1002/art.24248. Publication link: b9a8420f-1419-4707-a931-b26c11661d26 | PubMed:19180480
    • Pockert, A. J., Richardson, S. M., Le Maitre, C. L., Lyon, M., Deakin, J. A., Buttle, D. J., ... Hoyland, J. A. (2009). Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration. Arthritis and Rheumatism, 60(2), 482-491. DOI: 10.1002/art.24291. Publication link: 08bdfbcf-a39f-4b5b-9610-4c7b5d5fc443 | PubMed:19180493
    • Richardson, S. M., Doyle, P., Minogue, B. M., Gnanalingham, K., & Hoyland, J. A. (2009). Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. Arthritis Research and Therapy, 11(4), [R126]. DOI: 10.1186/ar2793. Publication link: b3c82876-b50e-4c7f-8701-1b1991fa4453 | PubMed:19695094
  • 2008

    Article

    • Ali, R., Le Maitre, C. L., Richardson, S. M., Hoyland, J. A., & Freemont, A. J. (2008). Connective tissue growth factor expression in human intervertebral disc: Implications for angiogenesis in intervertebral disc degeneration. Biotechnic and Histochemistry, 83(5), 239-245. DOI: 10.1080/10520290802539186. Publication link: 97dfeead-c37e-4fa1-8927-b493f47252b9 | PubMed:19016368
    • Kalson, N. S., Richardson, S., & Hoyland, J. A. (2008). Strategies for regeneration of the intervertebral disc. Regenerative Medicine, 3(5), 715-729. DOI: 10.2217/17460751.3.5.717. Publication link: 991654b7-93e6-4d8c-9332-09f40d30a583 | PubMed:18729796
    • Le Maitre, C. L., Frain, J., Fotheringham, A. P., Freemont, A. J., & Hoyland, J. A. (2008). Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure. Biorheology, 45(5), 563-575. DOI: 10.3233/BIR-2008-0498. Publication link: b1f51d54-dfde-43aa-90cf-560068e84408 | PubMed:19065005
    • Purmessur, D., Freemont, A. J., & Hoyland, J. A. (2008). Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc. Arthritis Research and Therapy, 10(4), [R99]. DOI: 10.1186/ar2487. Publication link: ad5ac203-8392-4cfb-90ff-15451b1d01b5 | PubMed:18727839
    • Richardson, S. M., & Hoyland, J. A. (2008). Stem cell regeneration of degenerated intervertebral discs: Current status. Current Pain and Headache Reports, 12(2), 83-88. DOI: 10.1007/s11916-008-0016-3. Publication link: e9ed0cbd-0f01-4776-b569-1cd4d3834c14 | PubMed:18474185
    • Richardson, S. M., Knowles, R., Tyler, J., Mobasheri, A., & Hoyland, J. A. (2008). Expression of glucose transporters GLUT-1, GLUT-3, GLUT-9 and HIF-1α in normal and degenerate human intervertebral disc. Histochemistry and Cell Biology, 129(4), 503-511. DOI: 10.1007/s00418-007-0372-9. Publication link: 49bee75c-4ec4-4a47-8ce9-458137921cdc
  • 2007

    Article

    • Le Maitre, C. L., Freemont, A. J., & Hoyland, J. A. (2007). Accelerated cellular senescence in degenerate intervertebral discs: A possible role in the pathogenesis of intervertebral disc degeneration. Arthritis Research and Therapy, 9, [R45]. DOI: 10.1186/ar2198. Publication link: 905c1a33-8e56-4d6f-8932-969dc4eb5931 | PubMed:17498290
    • Le Maitre, C. L., Hoyland, J. A., & Freemont, A. J. (2007). Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: An in situ zymographic and gene therapy study. Arthritis Research and Therapy, 9(4), [R83]. DOI: 10.1186/ar2282. Publication link: 8f33058a-eafb-408c-84bc-d9b10534564b | PubMed:17760968
    • Le Maitre, C., Hoyland, J. A., Le, M. C. L., & Freemont, A. J. (2007). Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1 beta and TNF alpha expression profile.Arthritis Res Ther, 9( 4). . Publication link: 4802eb20-32ad-4371-9aab-dfa901492710
  • 2006

    Article