What we do
Tissue Injury and Repair encompasses those individuals (both scientists and clinicians) with a research focus in tissue development/ structure, homeostasis and regeneration from the level of cellular and molecular mechanisms of injury and repair through to clinical impact.
It is a cohesive interdisciplinary team with well established collaborations in the Faculties of Life Sciences (FLS) and Engineering and Physical Sciences (EPS) and a number of world-leading institutions ensuring a multi-faceted research focus and a drive towards the development and clinical application of novel therapies.
The centre has a strong laboratory base and utilises a range of molecular, cellular and structural approaches to bear on its current strategy to:
- Understand fundamental aspects of tissue structure and homeostasis
- Develop new multi-disciplinary approaches to tissue repair and regeneration including the use of stem/progenitor cells and novel biomaterials.
Find out more about our UK Medical Research Council and National Institute for Health Research funded methodology research.
The interests of the centre focus on three areas:
- Tissue injury resulting from age-related and degenerative processes, exogenous factors (e.g. trauma/surgery) and endogenous factors (e.g. ischaemia/ inflammation)
- Tissue engineering and adult stem cell based regenerative medicine therapies for musculoskeletal, connective tissue and muscle disorders and peripheral nerve injuries
- Development of nanomedicine constructs based on nanscale materials of synthetic or biological nature for therapeutic or diagnostic applications.
Key research themes within the centre include:
- Adult stem cell biology and musculoskeletal tissue engineering
- Cell therapies for genetic disorders of muscle and connective tissue
- Intervertebral disc degeneration and regeneration
- Molecular mechanics
- Peripheral nerve (Blond McIndoe Laboratories)
- Polymers and biomaterials for tissue engineering and regenerative medicine therapies
- Tissue repair