Scleroderma and Raynauds Research Tissue Bank
The Scleroderma and Raynaud's Research Bank was set up in 2009 with the support of Salford Royal NHS Foundation Trust.
Consisting of DNA, serum, skin biopsies, calcinotic lumps and anonymised clinical and demographic data, this represents an important clinical resource in investigations of the cellular and molecular pathobiology and pathophysiology of systemic sclerosis and primary Raynaud's phenomenon, including genetic studies to define genotypes (a person's genetic makeup) that might be involved in pathogenesis (disease development).
The University of Manchester acts as the custodian of donated samples and data and issues such as consent, confidentiality and security of data are guided by the Salford Royal NHS Foundation Trust and the University research governance framework.
All samples and data are treated with respect, with total confidentiality and in accordance with donor consent.
- Anticentromere antibody, disease duration and history of surgical debridements predict calcinosis in patients with systemic sclerosis (PDF 2014)
- Calcinosis preferentially affects the thumb compared to other fingers in patients with systemic sclerosis (PDF 2014)
- What are systemic sclerosis-related calcinoses made of and can we dissolve them? (PDF 2014 3rd World SSc Congress)