Taking part in our research

Research in Osteoarthritis Manchester (ROAM), is part of the Institute of Inflammation and Repair at the University of Manchester. Directed by Professor David Felson, the team focus on testing and evaluating new medical devices and medicinal products for the treatment of knee osteoarthritis.

You can play a part in research by participating in our studies.

What studies can I take part in?

ROAM are currently looking for people to take part in the following study:

Trial name: DISKO - The Effect of Denosumab on Pain and Bone Marrow Lesions in Symptomatic Knee Osetoarthritis: A Randomised Double Blind Placebo Controlled Clinical Trial.

Chief Investigator: - Professor Terence O'Neill

What is the purpose of the study?

Osteoarthritis (OA) is the most common type of arthritis and causes joint pain, swelling and difficulties with day to day activities. DISKO is a study looking at OA affecting the knee. Current treatments for knee OA are limited as they have been shown to only work for short periods and are not effective for all patients. In addition, some people find that many of these treatments have side-effects and so they have to stop taking the medication.   

Denosumab is a treatment which is now used to treat people with fragile bones (Osteoporosis).  It is given as an injection under the skin and has relatively few side-effects.  There is some evidence that certain drugs which have been used to treat osteoporosis may also help reduce knee pain in people with knee osteoarthritis.  

The purpose of this study is to find out whether denosumab is effective at reducing pain and structural damage in knee OA.

Click here to find out more details about the DISKO trial.

How do I find out more information about how to take part?

Text 'KNEE' to 60066 to receive a call from the study team or call 0161 306 0545 / 0161 306 0547 to find out more information Contacts page