Our Research

Research in Osteoarthritis Manchester (ROAM), is part of the Institute of Inflammation and Repair at the University of Manchester. Directed by Professor David Felson, the team focus on testing and evaluating new medical devices and medicinal products for the treatment of knee osteoarthritis.

Our research is funded by the NIHR/Biomedical Research Unit and Arthritis Research UK.


Current studies

DISKO: The Effect of Denosumab on Pain and Bone Marrow Lesions in Symptomatic Knee Osetoarthritis: A Randomised Double Blind Placebo Controlled Clinical Trial.

Chief Investigator - Professor Terence O'Neill. 

Click here for more informaton


Previous studies run by the ROAM group (no longer recruiting)

    Professor David Felson - The Effect of lateral wedge INsoles on pain in individuals with medial Osteoarthritis who biomechanically RESPOND. The IN-RESPOND study.
    Dr Richard Jones (University of Salford) - Effect of lateral WEDGE insoles on Osteoarthritis knee pain and joint loading.
    Dr Michael Callaghan - Patellofemoral brace treatment in patients with chronic painful patellofemoral osteoarthritis (PFOA)
  • SILK
    Dr Richard Jones (University of Salford) - The effectiveness of Shoes and Insoles on the Loading at the Knee in subjects with knee osteoarthritis
  • TASK
    Professor Terence O'Neill - TArgeting Synovitis in Knee Osteoarthritis
  • HERO
    Professor Terence O'Neill - Hydroxychloroquine Effectiveness in Reducing Symptoms of hand Osteoarthritis

To read about our study findings, visit our publications page