University Hospital of South Manchester (UHSM) hosts the:
- National Pilot Allergy Centre
- National Aspergillosis Centre' and
- North West Lung Centre
(serving a catchment of 5 million), providing access to exceptionally well phenotyped patients in our themed disease areas.
Respiratory and Allergy Clinical Research Facility
We lead the only NIHR Respiratory and Allergy Clinical Research Facility in England (UHSM RACRF), which is co-located on a single site with the University of Manchester basic science laboratories.
Medicines Evaluation Unit
We house the Medicines Evaluation Unit (MEU; 100% charity owned), a 36-bed early-phase respiratory clinical trials facility with MHRA phase 1 accreditation, which is recognised for efficient execution and delivery of commercial studies in asthma and Chronic obstructive pulmonary disease (COPD).
The RACRF and MEU work as partners in the area of respiratory medicine; the RACRF performs the 'science' of experimental medicine (phenotyping, biomarker development, optimisation of study designs across a broad portfolio). These strong facilities and partnerships provide a platform to cement our position as one of the UK leaders in asthma and COPD, and expand experimental medicine in the neglected areas of food allergy, fungal lung disease and chronic cough.
Our patient collections include the:
- Manchester Asthma and Allergy Study birth cohort (n~1000),
- joint MEU and RACRF Asthma/COPD Trials database (n~5000),
- Manchester Centre of the British Thoracic Society Registry of Severe Asthma (n~500).
Manchester Respiratory and Allergy Biobank
We have established our unique Research Tissue Bank, (the Manchester Respiratory and Allergy Biobank; ManRAB). Patients attending clinic in our themed areas are targeted for thorough assessments for ManRAB. Biological samples are tracked throughout handling in the laboratory management system then stored in our purpose-built storage facility. Quarterly audits are conducted by the ManRAB data monitoring committee, and access is granted to researchers through agreed protocols.