Research in the Centre for Musculoskeletal Research (CfMR) is undertaken by established groups and independent researchers investigating genetic and epidemiological aspects of musculoskeletal conditions.
We have made major contributions to the understanding of the genetic basis of the common types of inflammatory arthritis under long-term care in rheumatology clinics; rheumatoid arthritis (RA), psoriatic arthritis (PsA) and juvenile idiopathic arthritis (JIA).
We also lead in studies of the epidemiology of RA defining environmental risk factors for susceptibility and outcome.
For systemic lupus erythematosus (SLE) we have defined risk factors for cardiovascular outcome.
In pain research we have identified factors associated with reporting of chronic widespread pain in older people.
Translation of these findings for patient benefit is recognised as a priority. Our research on treatment response and development of serious adverse events for patients treated on biologic therapies is internationally leading and has informed the development of treatment guidelines through two NICE technology appraisals.
- Centre for Epidemiology Versus Arthritis (formerly the Arthritis Research UK Centre for Epidemiology)
- Centre for Genetics and Genomics Versus Arthritis (formerly the Arthritis Research UK Centre for Genetics and Genomics)
- NIHR Manchester Biomedical Research Centre - Musculoskeletal Theme
- Cochrane Bone, Joint and Muscle Trauma Group
- Independent Researcher Programmes
The CfMR has a number of affiliated members from across the Faculty of Biology, Medicine and Health and other disciplines within the University of Manchester, demonstrating the broad range of research activities undertaken.
Major research consortia
We are members of several national and international consortia, including:
- MATURA Consortium (Maximising therapeutic utility in rheumatoid arthritis)
- WTCCC (Wellcome Trust Case Control Consortium)