The Manchester Fungal Infection Group (MFIG) is a new international centre of excellence for fungal infection biology and translational antifungal research at the University of Manchester. It is integrating its research with that of clinicians and industry.
To understand and reduce the burden of human fungal diseases
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(Image : Asexual structures of Apergillus niger)
Using the human pathogen Aspergillus fumigatus as our main experimental system, MFIG’s research is focused on four integrated themes:
Fungal cell biology, Host-pathogen interactions, Genetics and genomics and Antifungal drug discovery
Learn more about us in our downloadable MFIG booklet
- Professor Nick D Read (Director)
The Cell biology of colony initiation and infection; fungal calcium signalling; antifungal peptides
- Dr Elaine Bignell (Co-Director)
Host-pathogen interactions; pH sensing
- Dr Paul Bowyer
Genomics and genetics; antifungal resistance
- Dr Mike Bromley
Antifungal drug discovery; high throughput gene deletion and library screening
- Dr Jorge Amich
Fungal pathogen metabolism; re-engineering sulphur metabolism
MFIG in the Scientific Community:
MFIG Director Nick Read has worked in collaboration with academic partners at the The University of Edinburgh (Dr Marc Vendrell), University of Barcelona and IRB Barcelona (Professor Rodolfo Lavilla) to develop dynamic activatable fluorophores, specially developed to enable fluorogenic labelling of peptides for enhanced live-cell imaging.
Major Wellcome Trust Funding to Dr Michael Bromley & Colleagues,
Drs Michael Bromley, Paul Bowyer and Prof Daniela Delniri have been awarded a Wellcome Trust Biomedical Resources Grant. ‘The Aspergillus fumigatus gene and non-coding RNA knockout library’
N8 AgriFood funding to Michael Bromley& Colleagues
Dr Mike Bromley and colleagues have been awarded £40, 000 to improve the Biocontrol of Aflatoxin Production in Maize. £40,000.
British Society for Antimicrobial Chemotherapy Funding for Drs Jorge Amich & Elaine Bignell
Dr Jorge Amich and Dr Elaine Bignell have been awarded a 4 year PhD studentship, from the British Society for Antimicrobial Chemotherapy (BSAC), to study fungal methionine syntheses as novel antifungal drug targets.
MRC Confidence in Concept Funding to Dr Mike Bromley
Dr Mike Bromley has been awarded a 12 month MRC Confidence in Concept Award to study the efficacy of DNA minor groove binders as novel antifungal agents
Two visiting Erasmus students have joined the group until December 2017: Daiana Macedo and Maria Corrochano Luque.
Press Releases :
- Profs David Denning and Malcolm Richardson speak to the CDC on antimicrobial resisrance.
- MFIG director prof Nick Read signs deal with Merck for pioneering fluorescent probe technology.
- How fungi kill millions globally: David Denning speaks to CNN
- Killer Fungi: The health threat that's creeping up on us in New Scientist
- Fungicides for crops: worrying link to fungal drug resistance in UK warn scientists
- Dr Jorge Amich presented a talk at the Irish Fungal Society meeting in Limerick, Ireland on 15th June.
- Omar Loss, Margherita Bertuzzi, Yu Yan, Natalie Fedorova, Bethany L McCann, Darius Armstrong‐James, Eduardo A Espeso, Nick D Read, William C Nierman, Elaine M Bignell (2017) Mutual independence of alkaline- and calcium-mediated signalling in Aspergillus fumigatus refutes the existence of a conserved druggable signalling nexus. Mol Microbiol. doi: 10.1111/mmi.13840. [Epub ahead of print]
- Panagiotis Papastamoulis, Takanori Furukawa, Norman Van Rhijn, Michael Bromley, Elaine Bignell, Magnus Rattray (2017) Bayesian detection of piecewise linear trends in replicated time-series with application to growth data modelling arXiv preprint arXiv:1709.06111
- Lorena Mendive-Tapia, Ramon Subiros-Funosas, Can Zhao, Fernando Albericio, Nick D Read, Rodolfo Lavilla & Marc Vendrell (2017) Preparation of a Trp-BODIPY fluorogenic amino acid to label peptides for enhanced live-cell fluorescence imaging Nature Protocols 12:1588–1619 doi:10.1038/nprot.2017.048
- Sergio D. Moreno-Velásquez, Constanze Seidel, Praveen R. Juvvadi, William J. Steinbach and Nick D. Read (2017) Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in β-1,3-Glucan Synthase Localization Antimicrob Agents Chemother doi: 10.1128/AAC.00710-17
- Johns A, Scharf DH, Gsaller F, Schmidt H, Heinekamp T, Straßburger M, Oliver JD, Birch M, Beckmann N, Dobb KS, Gilsenan J, Rash B, Bignell E, Brakhage AA, Bromley MJ. (2017). A nonredundant phosphopantetheinyl transferase, PptA, is a novel antifungal target that directs secondary metabolite, siderophore, and lysine biosynthesis in Aspergillus fumigatus and is critical for pathogenicity. mBio 8:e01504-16. https://doi.org/10.1128/mBio.01504-16.