The Manchester Fungal Infection Group (MFIG) is a new international centre of excellence for fungal infection biology and translational antifungal research at the University of Manchester. It is integrating its research with that of clinicians and industry.
To understand and reduce the burden of human fungal diseases
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(Image : Asexual structures of Apergillus niger)
Using the human pathogen Aspergillus fumigatus as our main experimental system, MFIG’s research is focused on four integrated themes:
Fungal cell biology, Host-pathogen interactions, Genetics and genomics and Antifungal drug discovery
Learn more about us in our downloadable MFIG booklet
- Professor Nick D Read (Director)
Cell biology of colony initiation and infection; fungal calcium signalling; antifungal peptides
- Dr Elaine Bignell (Deputy Director)
Host-pathogen interactions; pH sensing
- Dr Paul Bowyer
Genomics and genetics; antifungal resistance
- Dr Mike Bromley
Antifungal drug discovery; high throughput gene deletion and library screening
- Dr Jorge Amich
Fungal pathogen metabolism; re-engineering sulphur metabolism
MFIG in the Scientific Community:
Dr Margherita Bertuzzi wins best oral presentation prize at BSMM 2017. Sergio Velasques also gave a talk.
Drs Margherita Bertuzzi and Elaine Bignell are awarded an MRC Discovery Award in Single Cell Analysis to study the antifungal potency of the airway epithelium in health and disease.
Dr Sara Gago is awarded an NC3IR fellowship award to develop new experimental models to understand the genetic basis of ABPA.
Dr Margherita Bertuzzi presented data at the Gordon research seminar and conference in Galveston, USA.
MFIG celebrates diversity of fungal science with "Fungi: friend or foe" exhibition at Science Spectacular and marks 25 years of Fungal Infection Trust.
Dr Peter Cook presents data at the MRC Centre for Medical Mycology at the University of Aberdeen on "Defining key checkpoints in dendritic cell control of anti-fungal immunity and inflammation".
Dr Elaine Bignell presented at IFoFun-2016 Virulence Mechanisms of Phyto- and Human-Pathogenic Fungi meeting in Erlangen, Germany.
Dr Fabio Gsaller presented a talk and won the poster prize at the German Mycological Society meeting in Essen, Germany.
Dr Elaine Bignell speaks at the Royal Society's 'Tackling emerging fungal threats to animal health, food security and ecosystem resilience' meeting.
Press Releases :
- Profs David Denning and Malcolm Richardson speak to the CDC on antimicrobial resisrance.
- MFIG director prof Nick Read signs deal with Merck for pioneering fluorescent probe technology.
- How fungi kill millions globally: David Denning speaks to CNN
- Killer Fungi: The health threat that's creeping up on us in New Scientist
- Fungicides for crops: worrying link to fungal drug resistance in UK warn scientists
- Dr Sylvain Brun (University of Paris Diderot) visits MFIG for 6 months to learn advanced live-cell imaging techniques in Nick Read's lab to study nuclear movments
during Neurospora crassa fertilization.
- MFIG welcomes Professor Michelle Momany (University of Georgia) to Manchester on a Royal Society-funded Exchange Scheme (Momany/Bignell).
- Dr Maiko Umemura visits MFIG as a visiting researcher from Sapporo, Japan to join the Bignell lab.
Accumulation of specific sterol precursors targets a MAP kinase cascade mediating cell–cell recognition and fusion, Weichart et al., 2016, PNAS
Genetic susceptibility to allergic bronchopulmonary aspergillosus in asthma: a genetic association study, Oveton et al., 2016, Allergy, Asthman and Clinnical Immunology
Amino acid biosynthetic routes as drug targets for pulmonary fungal pathogens: what is known and why do we need to know more? Amich & Bignell, 2016, Current Opinion in Microbiology
Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex, Gsaller et al., 2016, PLoS Pathogens
Electrophilic, Activation-Free Fluorogenic Reagent for Labeling Bioactive Amines, Sintes et al., 2016, Bioconjugate Chemistry
Antifungal mechanisms of a plant defensin MtDef4 are not conserved between the ascomycete fungi Neurospora crassa and Fusarium graminearum, El-Mounadi et al., 2016, Molecular Microbiology
Palmitoylation of the Cysteine Residue in the DHHC Motif of a Palmitoyl Transferase Mediates Ca2+ Homeostasis in Aspergillus, Zhang et al., 2016, PLoS Genetics
Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue, Mendive-Tapia et al., 2016, Nature Communications