Mechanisms of occupational asthma
Occupational asthma hazard prediction
J Jarvis, Martin Seed, Raymond Agius
Research on asthma that has been undertaken includes the development and validation of techniques to predict occupational asthma hazard from chemical structure. A programme was developed for this purpose and has been validated. Key publications by us on this subject are the following:
- Further validation of computer-based prediction of chemical asthma hazard
Occupational Medicine 2010; 60: 115-120
Seed MJ, Agius R.
- Relationship between chemical structure and the occupational asthma hazard of low molecular weight organic compounds
Occupational and Environmental Medicine 2005; 62: 243-250
Jarvis J, Seed MJ, Elton R, Sawyer L, Agius R.
As mentioned in the above cited publications, a logistic regression model was developed for predicting the occupational asthma hazard of Low Molecular Weight chemicals.
Occupational asthma hazard prediction programme
Access to the web-based version is at: Occupational asthma hazard prediction programme. You will need a username and password to access this.
Further application and validation of the above tool continues. If you have used it, we would be grateful if you could feedback your results, comments (such as on how useful or easy you found it) and any queries by email to Dr Martin Seed: Martin.Seed@manchester.ac.uk
For other research that is related to asthma, such as on the incidence of occupational asthma as reported through the THOR network (SWORD and OPRA), or for research on air pollution and health, please return to the parent directory.
- Evaluation questionnaire for asthma hazard prediction programme (PDF, 247 KB)
Please assist us by completing a brief questionnaire on the programme and returning it to us at the COEH.
Open this MOL file for toluene diisocyanate (it has been converted to a Word document), then copy and paste into the prediction programme to see the results.
ChemExper chemical directory
The ChemExper chemical directory can identify the structure and convert to molfile any given chemical name or CAS registry number.
In order to better inform the public about occupational asthma, the prinicpal investigator for this research (Prof Raymond Agius) has made the following website available: