Diabetes is defined by a failure to control circulating glucose levels within set limits due to inadequate amounts and/or action of the hormone insulin. Insulin is secreted from the beta-cells of the pancreatic islets and regulates much of the body’s metabolism, not just glucose levels. Cellular damage due to long-term diabetes affects many organs and tissues including the eyes, kidneys, nerves and the heart. Because of this complexity and importance, diabetes has grown into its own specialty alongside endocrinology.
Clinical diabetes cares for patients with two main sub-types of the disorder:
- Type 1 diabetes due to autoimmune destruction of the beta cells and total loss of insulin
- Type 2 diabetes reflecting inadequate insulin secretion and action
Both forms of the disorder are increasing rapidly making the specialty and care of patients a major international priority.
Our principal investigator-led research spans discovery science in the laboratory translated through to internationally-funded clinical trials and innovative new treatment strategies such as islet transplantation.
Our laboratory studies are facilitated by our:
- Centre for Integrative Mammalian Biology
- North West Embryonic Stem Cell Centre
- Wellcome Trust Centre for Cell-Matrix Research
Our clinical studies are facilitated by our:
- Northwest Diabetes Research Network (CLRN)
- Diabetes and Obesity Research Network
- Greater Manchester Comprehensive Local Research Network
- Manchester Academic Health Science Centre
- NIHR Manchester Biomedical Research Centre
- Manchester Wellcome Trust Clinical Research Facility
- Greater Manchester, Lancashire and Cumbria Medicines for Children Research Network