We have discovered that the hair follicle in mice and man is not only a prominent peripheral target organ for numerous (neuro-)endocrine mediators, but also serves itself as a potent, non-classical source for many neurohormones.

The challenge now is to elucidate the - generally still obscure - range of functional activities in hair biology and beyond that these intracutaneously synthesized neurohormones (such as prolactin, melatonin, CRH, ACTH, αMSH, endocannabinoids) exert, and to identify new target genes and activities. Furthermore, we attempt to clarify the regulation of intrafollicular neurohormone synthesis, metabolism and cognate receptor expression, and chart intrafollicular cross-signalling and cross-regulation between distinct neuroendocrine systems.