Ageing and photoageing
Ageing of the skin can be thought of as two, simultaneously occurring, processes.
First, there are changes that occur as a result of the passage of time; these intrinsic changes which produce fine wrinkles are associated with a loss of elastic fibres.
The second process is due to external factors such as chronic sun exposure. Such photoaged skin is deeply wrinkled and characterised by an accumulation of disorganised elastic fibre material.
We are employing biochemical and microscopical techniques to track the changes in extracellular matrix molecules in aged and photoaged skin.