Randomised trials of complex interventions in mental health
This workshop was held on 19th January 2016.
The slides from the workshop are availabile below.
If you have any queries, please contact Richard Emsley for details.
This one day workshop will introduce participants to the latest research in statistical methodology to evaluate markers in trials of complex interventions in mental health. Broadly speaking, this research aims to answer four questions about complex interventions/treatments:
1. Does it work? Is there a beneficial effect of the treatment compared with some other treatment or treatment as usual?
2. How does it work? What are the underlying mechanisms or targets of the treatment?
3. Who does it work for? Are there subgroups of people who benefit most? Could the treatment be targeted to particular subgroups of the population?
4. What factors make it work better?
A summary of this research has been published and can be freely downloaded in:
Dunn G, Emsley R, Liu H, Landau S, Green J, White I, Pickles A. Evaluation and validation of social and psychological markers in randomised trials of complex interventions in mental health: a methodological research programme (2015). Health Technology Assessment, volume 19, number 93.
- Introduction to the Workshop (pdf, 336 kb)
- Does the treatment work and by how much? (pdf, 704 kb)
Dr Ian White (MRC Biostatistics Unit, Cambridge)
- How does the treatment work? (pdf, 850 kb)
Dr Richard Emsley (Centre for Biostatistics, The University of Manchester)
- Incorporating methodology in a clinical research programme (pdf, 495 kb)
Professor Jonathan Green (Centre for Developmental Science, The University of Manchester)
- What factors make the treatment work better? (pdf, 495 kb)
Professor Graham Dunn (Centre for Biostatistics, The University of Manchester)
- Who does the treatment work for? (pdf, 664 kb)
Professor Sabine Landau (IoPPN, King's College London)
Some of the datasets included in these presentations are free to download using the following link: Datasets and software.
The workshop was supported by:
MRC MRP COMPLEX grant (PI: Sabine Landau, MR/K006185/1)