Publications

  • 2017

    Article

    • Budu-Aggrey, A., Bowes, J., Stuart, P. E., Zawistowski, M., Tsoi, L. C., Nair, R. P., ... Raychaudhuri, S. (2017). A rare coding allele in IFIH1 is protective for psoriatic arthritis. Annals of the Rheumatic Diseases. . Publication link: 2b3e0f34-7dcc-4f25-b4ee-b8e966cdb3c3
    • Castelino, M., Eyre, S., Moat, J., Fox, G., Martin, P., Ho, P., ... Barton, A. (2017). Optimisation of methods for bacterial skin microbiome investigation: primer selection and comparison of the 454 versus MiSeq platform. BMC Microbiology, 17(1), [23]. DOI: 10.1186/s12866-017-0927-4. Publication link: f7b77966-3dcf-4399-b303-8dab68638b7f
    • Cui, J., Diogo, D., Stahl, E. A., Canhao, H., Mariette, X., Greenberg, J. D., ... Raychaudhuri, S. (2017). Brief Report: The Role of Rare Protein-Coding Variants in Anti–Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis. Arthritis and Rheumatology, 69(4), 735-741. DOI: 10.1002/art.39966. Publication link: 6950b525-4da2-4456-9d1f-79a93288b286
    • Hinks, A., Bowes, J., Cobb, J., Ainsworth, H. C., Marion, M. C., Comeau, M. E., ... Thomson, W. (2017). Fine-mapping the MHC locus in juvenile idiopathic arthritis (JIA) reveals genetic heterogeneity corresponding to distinct adult inflammatory arthritic diseases.Annals of the Rheumatic Diseases, 76(4), 765–772. DOI: 10.1136/annrheumdis-2016-210025. Publication link: fd9f6e13-a22b-4949-a75b-9566207b5443
    • Jani, M., Dixon, W., Kearsley-Fleet, L., Bruce, I., Chinoy, H., Barton, A., ... Hyrich, K. (2017). Drug-specific risk and characteristics of lupus and vasculitis-like events in rheumatoid arthritis patients treated with TNFi: results from BSRBR-RA. RMD Open, 3(1), e000314. DOI: 10.1136/rmdopen-2016-000314. Publication link: 8ea4593c-0eb4-4e80-b9d4-6524eff34bf6
    • Jani, M., Isaacs, J. D., Morgan, A. W., Wilson, A. G., Plant, D., Hyrich, K., ... Barton, A. (2017). High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort. Annals of the Rheumatic Diseases, 76(1), 208-213. DOI: 10.1136/annrheumdis-2015-208849. Publication link: d94b9994-66aa-4385-8c10-08ab2ebd93dc
    • Márquez, A., Vidal-Bralo, L., Rodríguez-Rodríguez, L., González-Gay, M. A., Balsa, A., González-álvaro, I., ... Martín, J. (2017). A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus. Annals of the Rheumatic Diseases, 76(1), 286-294. DOI: 10.1136/annrheumdis-2016-209436. Publication link: cb95b875-ca71-4a10-a604-eb53f43da98c
    • Ombrello, M. J., Arthur, V. L., Remmers, E. F., Hinks, A., Tachmazidou, I., Grom, A., ... Thomson, W. (2017). Genetic Architecture Distinguishes Systemic Juvenile Idiopathic Arthritis from Other Forms of Juvenile Idiopathic Arthritis: Clinical and Therapeutic Implications. Annals of the Rheumatic Diseases. DOI: 10.1136/annrheumdis-2016-210324. Publication link: 9362cac0-0bea-4e1a-9db4-fdb12c949901
    • Smith, S., Plant, D., Eyre, S., Hyrich, K., Morgan, A. W., Wilson, A. G., ... Barton, A. (2017). The Predictive Value of Serum S100A9 and Response to Etanercept is not Confirmed in a Large UK Rheumatoid Arthritis Cohort.Rheumatology. DOI: 10.1093/rheumatology/kew387. Publication link: 6f000cb9-bee6-4f60-9ddb-b746aa11ccff
    • Viatte, S., & Barton, A. (2017). Genetics of rheumatoid arthritis susceptibility, severity and treatment response. Seminars in Immunopathology. DOI: 10.1007/s00281-017-0630-4. Publication link: 84d47730-6e59-4c50-a145-70e45e67afc4

    Letter

  • 2016

    Article

    • Barton, A., & Pitzalis, C. (2016). Stratified medicine in rheumatoid arthritis – the MATURA programme.Rheumatology. . Publication link: d3bd4a0c-2524-45f2-8497-be2ad9fc635b
    • Budu-Aggrey, A., Bowes, J., & Barton, A. (2016). Identifying a novel locus for Psoriatic Arthritis. Rheumatology, 55(1), 25-32. DOI: 10.1093/rheumatology/kev273. Publication link: 76e180a9-503e-4ecf-8e67-50da6f48d9b2
    • Davies, R., Carrasco, R., Foster, H. E., Eileen M. Baildam, S E Alice Chieng, Joyce E. Davidson, ... Hyrich, K. (2016). Treatment prescribing patterns in patients with juvenile idiopathic arthritis (JIA): analysis from the UK Childhood Arthritis Prospective Study (CAPS). Seminars in Arthritis and Rheumatism, 46(2), 190-195. DOI: 10.1016/j.semarthrit.2016.06.001. Publication link: be153ceb-15c9-4e05-b86d-0606bef875b9
    • Ellinghaus, D., Jostins, L., Spain, S. L., Cortes, A., Bethune, J., Han, B., ... International IBD Genetics Consortium (IIBDGC) (2016). Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nature Genetics, 48(5), 510-518. DOI: 10.1038/ng.3528. Publication link: b8c2a495-6e2f-465c-9687-78a546d88199 | PubMed:26974007
    • Gusev, A., Shi, H., Kichaev, G., Pomerantz, M., Li, F., Long, H. W., ... PRACTICAL consortium (2016). Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation. Nature communications, 7, [10979]. DOI: 10.1038/ncomms10979. Publication link: 09d6812c-d622-4547-90cc-0cea47257fa6 | PubMed:27052111
    • Gutierrez-Achury, J., Zorro, M. M., Ricaño-Ponce, I., Zhernakova, D. V., Diogo, D., Raychaudhuri, S., ... Zhernakova, A. (2016). Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis.Human molecular genetics, 25(1), 180-190. DOI: 10.1093/hmg/ddv455. Publication link: 6e9dc983-39a5-4dcb-849e-0531beb0eab6 | PubMed:26546613
    • Gutierrez-Arcelus, M., Rich, S. S., & Raychaudhuri, S. (2016). Autoimmune diseases - connecting risk alleles with molecular traits of the immune system. Nature Reviews Genetics, 17(3), 160-74. DOI: 10.1038/nrg.2015.33. Publication link: 80afc48a-f8f2-42d1-a0aa-832f87614bcf | PubMed:26907721
    • Han, B., Duong, D., Sul, J. H., de Bakker, P. I. W., Eskin, E., & Raychaudhuri, S. (2016). A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping. Human Molecular Genetics, 25(9), 1857-66. DOI: 10.1093/hmg/ddw049. Publication link: b5651407-6fdf-448a-97c5-6ec99c28d5ab | PubMed:26908615
    • Han, B., Pouget, J. G., Slowikowski, K., Stahl, E., Lee, C. H., Diogo, D., ... Raychaudhuri, S. (2016). A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nature Genetics, 48(7), 803 - 810. DOI: 10.1038/ng.3572. Publication link: d7bd7cb4-db9f-429e-82e1-f4dcb1ba5068
    • Hope, H. F., Bluett, J., Barton, A., Hyrich, K., Cordingley, L., & Verstappen, S. (2016). Psychological factors predict adherence to methotrexate in rheumatoid arthritis; findings from a systematic review of rates, predictors and associations with patient-reported and clinical outcomes. RMD Open, 2(1), e000171. DOI: 10.1136/rmdopen-2015-000171. Publication link: a2f007b2-06c3-4907-a626-990b2cf5a91d
    • Humphreys, J. H., Verheul, M. K., Barton, A., MacGregor, A. J., Lunt, M., Toes, R. E., ... Verstappen, S. M. (2016). Anti-carbamylated protein antibodies are associated with long term disability and increased disease activity in patients with early inflammatory arthritis: results from the Norfolk Arthritis Register (NOAR). Annals of the Rheumatic Diseases, 75(6), 1139-1144. DOI: 10.1136/annrheumdis-2015-207326. Publication link: 98833ff0-9102-4fea-ba9e-8519920c14e8
    • Hyrich, K. L., Baildam, E., Pickford, H., Chieng, A., Davidson, J. E., Foster, H., ... Thomson, W. (2016). Influence of past breast feeding on pattern and severity of presentation of juvenile idiopathic arthritis. Archives of Disease in Childhood, 101(4), 348-351. DOI: 10.1136/archdischild-2014-308117. Publication link: 90d78c20-bfbf-42b8-bb18-259b0bf5b62e
    • Jani, M., Gavan, S., Dixon, W., Harrison, B., Moran, A., Barton, A., & Payne, K. (2016). A microcosting study of immunogenicity and TNFi drug level tests for therapeutic drug monitoring in clinical practice. Rheumatology, 55(12), 2131-2137. DOI: 10.1093/rheumatology/kew292. Publication link: 2941b3fc-b830-4586-8857-a063e0fd10a0
    • Jani, M., Isaacs, J. D., Morgan, A. W., Wilson, A. G., Plant, D., Hyrich, K., ... Barton, A. (2016). Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels. Rheumatology, 55(11), 2050-2055. DOI: 10.1093/rheumatology/kew299. Publication link: 34b034f5-1a54-45c7-b700-2c4aae1a4b63
    • Kearsley-Fleet, L., Davies, R., Baildam, E., Beresford, M. W., Foster, H. E., Southwood, T. R., ... Hyrich, K. L. (2016). Factors associated with choice of biologic among children with juvenile idiopathic arthritis: Results from two UK paediatric biologic registers. Rheumatology (Print), 55(9), 1556-1565. DOI: 10.1093/rheumatology/kev429. Publication link: 9d0265d3-4f30-4284-8479-b6cb7d0de7e3
    • Kumar, K., Peters, S., & Barton, A. (2016). Rheumatoid arthritis patient perceptions on the value of predictive testing for treatments: a qualitative study. BMC Musculoskeletal Disorders, 17(1), [460]. DOI: 10.1186/s12891-016-1319-x. Publication link: 57c0032c-220a-4a54-a5c6-0bf8bad027f7
    • Ling, S., Viatte, S., Lunt, M., Van Sijl , A. M., Silva-Fernandez, L., Symmons, D., ... Barton, A. (2016). HLA–DRB1 Amino Acid Positions 11/13, 71, and 74 Are Associated With Inflammation Level, Disease Activity, and the Health Assessment Questionnaire Score in Patients With Inflammatory Polyarthritis. Arthritis and Rheumatology, 68(11), 2618-2628. DOI: 10.1002/art.39780. Publication link: e86d5ff4-659e-45dd-b3e0-66a8bb080cc6
    • López-Isac, E., Campillo-Davo, D., Bossini-Castillo, L., Guerra, S. G., Assassi, S., Simeón, C. P., ... Oreiro, N. (2016). Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.Annals of the rheumatic diseases, 75(8), 1521-1526. DOI: 10.1136/annrheumdis-2015-208154. Publication link: c02241a4-87a1-46e3-b8d9-5f19427cbf63 | PubMed:26338038
    • López-Isac, E., Martin, J-E., Assassi, S., Simeon, C. P., Carreira, P., Ortego-Centeno, N., ... Martin, J. (2016). Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies. Arthritis and Rheumatology, 68(9), 2338-44. DOI: 10.1002/art.39730. Publication link: 0cf71219-83be-4d57-8b5c-af959f1c9fd5
    • Martin, P., Mcgovern, A., Massey, J., Schoenfelder, S., Duffus, K., Yarwood, A., ... Orozco, G. (2016). Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C. PLoS ONE, 11(11), [ e0166923]. DOI: 10.1371/journal.pone.0166923. Publication link: 4a694ff6-b1db-420c-99d8-b19497948d8c
    • Mcerlane, F., Foster, H. E., Carrasco, R., Baildam, E. M., Chieng, S. E. A., Davidson, J. E., ... Hyrich, K. (2016). Trends in paediatric rheumatology referral times and disease activity indices over a ten-year period among children and young people with juvenile idiopathic arthritis: results from the Childhood Arthritis Prospective Study. Rheumatology (Print), 55(7), 1225-34. DOI: 10.1093/rheumatology/kew021. Publication link: c6ecc7e2-c2c0-4a1e-874b-c263addd3a6f
    • Mcgovern, A., Schoenfelder, S., Martin, P., Massey, J., Duffus, K., Plant, D., ... Orozco, G. (2016). Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23. Genome Biology, [212]. DOI: 10.1186/s13059-016-1078-x. Publication link: 12d9bfcf-12c8-45e3-9ba6-c81fbd5f444c
    • Parsons, S., Dack, K., Starling, B., Thomson, W., & Mcdonagh, J. (2016). Study protocol:: Determining what young people with rheumatic disease consider important to research (the Young People’s Opinions Underpinning Rheumatology Research - YOURR project). Research Involvement and Engagement, 2(22), [22]. DOI: 10.1186/s40900-016-0037-8. Publication link: 42ccf6ef-597f-4911-b8a1-b9532ffac780
    • Plant, D., Webster, A., Nair, N., Oliver, J., Smith, S. L., Eyre, S., ... Barton, A. (2016). Differential methylation as a biomarker of response to etanercept in patients with rheumatoid arthritis. Arthritis & Rheumatism, 68(6), 1353–1360. DOI: 10.1002/art.39590. Publication link: d1a7db48-ab2d-45f8-8487-edb824eac51d
    • Pouget, J. G., Gonçalves, V. F., Spain, S. L., Finucane, H. K., Raychaudhuri, S., Kennedy, J. L., ... Schizophrenia Working Group of the Psychiatric Genomics Consortium (2016). Genome-Wide Association Studies Suggest Limited Immune Gene Enrichment in Schizophrenia Compared to 5 Autoimmune Diseases. Schizophrenia bulletin, 42(5), 1176-1184. DOI: 10.1093/schbul/sbw059. Publication link: bfab0692-cbbb-4ebc-bfde-79a16717a071 | PubMed:27242348
    • Prins, B. P., Abbasi, A., Wong, A., Vaez, A., Nolte, I., Franceschini, N., ... PAGE Consortium (2016). Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. PL o S Medicine, 13(6), e1001976. DOI: 10.1371/journal.pmed.1001976. Publication link: 609e5fce-c8a0-4600-a5df-cc5a66c79a93 | PubMed:27327646
    • Ray-Jones, H., Eyre, S., Barton, A., & Warren, R. B. (2016). One SNP at a Time: Moving beyond GWAS in Psoriasis.The Journal of investigative dermatology, 136(3), 567-573. DOI: 10.1016/j.jid.2015.11.025. Publication link: f987af9c-ef5e-4522-afa3-9b9c96cff499 | PubMed:26811024
    • Sieberts, S. K., Zhu, F., García-García, J., Stahl, E., Pratap, A., Pandey, G., ... Mangravite, L. M. (2016). Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis. Nature Communications, 7, [12460]. DOI: 10.1038/ncomms12460. Publication link: 9e23b185-1063-4cb9-b54e-1b602abf93ec
    • Smith, R. L., Hébert, H. L., Massey, J., Bowes, J., Marzo-Ortega, H., Ho, P., ... Warren, R. B. (2016). Association of Toll-like receptor 4 (TLR4) with chronic plaque type psoriasis and psoriatic arthritis. Archives of Dermatological Research, 308(3), 201-205. DOI: 10.1007/s00403-016-1620-4. Publication link: 1f976e46-e5d6-43ca-9d36-50c22f1e45dd | PubMed:26830904
    • Smith, S. L., Plant, D., Lee, X. H., Massey, J., Hyrich, K., Morgan, A. W., ... Barton, A. (2016). Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in large UK rheumatoid arthritis cohort.Pharmacogenomics, 17(7), 715-20. DOI: 10.2217/pgs.16.16. Publication link: 09d1e455-c78b-4e3a-9a46-f0800945b200
    • van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., ... de Bakker, P. I. W. (2016). 52 Genetic Loci Influencing Myocardial Mass. Journal of the American College of Cardiology, 68(13), 1435-1448. DOI: 10.1016/j.jacc.2016.07.729. Publication link: 7074c946-2762-4c1d-afeb-e3de2e836772 | PubMed:27659466
    • Viatte, S., James C. Lee, Fu, B., Marion Espéli, Lunt, M., Jack N.E. De Wolf, ... Kenneth G.C. Smith (2016). Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis. Arthritis and Rheumatology, 68(11), 2629–2636. DOI: 10.1002/art.39760. Publication link: f3abbe39-b4cc-4a3e-8f8c-bf13fd01008f
    • Viatte, S., Massey, J., Bowes, J., Duffus, K., arcOGEN Consortium, Eyre, S., ... Worthington, J. (2016). Replication of genetic loci outside the HLA conferring susceptibility to anti-CCP negative rheumatoid arthritis.Arthritis & Rheumatology (Hoboken), 68(7), 1160-6. DOI: 10.1002/art.39619. Publication link: a8ee9dec-8f02-4f3b-b46f-3586ea069ab9 | PubMed:26895230
    • Viatte, S., Massey, J., Bowes, J., Duffus, K., Eyre, S., Barton, A., ... Zeggini, E. (2016). Replication of Associations of Genetic Loci Outside the HLA Region With Susceptibility to Anti–Cyclic Citrullinated Peptide–Negative Rheumatoid Arthritis. Arthritis & Rheumatology, 68(7), 1603-1613. DOI: 10.1002/art.39619. Publication link: fba7de2c-665f-496b-b366-1162ee1cc4f1
    • Wagner, E. K., Raychaudhuri, S., Villalonga, M. B., Java, A., Triebwasser, M. P., Daly, M. J., ... Seddon, J. M. (2016). Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD. Scientific Reports, 6, [31531]. DOI: 10.1038/srep31531. Publication link: 2523fe20-a583-4e6d-bcd4-0546b7358737
    • Webster, A. P., Smith, S., Worthington, J., Barton, A., & Plant, D. (2016). Cryopreservation of cells does not substantially alter the DNA methylome of CD3+CD4+ T cells. Scandinavian Journal of Rheumatology, 45(4), 329-30. DOI: 10.3109/03009742.2015.1115896. Publication link: edc14a9b-2f6f-4f5d-9d4f-f8ebed68fda5 | PubMed:26690697
    • Wei, W., Bowes, J., Plant, D., Viatte, S., Yarwood, A., Massey, J., ... Eyre, S. (2016). Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis. Scientific Reports, 6, [25014]. DOI: 10.1038/srep25014. Publication link: 70c6b9a5-135b-4a46-be16-f435a0c466e2
    • Wei, W-H., Loh, C-Y., Worthington, J., & Eyre, S. (2016). Immunochip analyses of epistasis in rheumatoid arthritis confirm multiple interactions within MHC and suggest novel non-MHC epistatic signals.The Journal of rheumatology, 43(5), 839-845. DOI: 10.3899/jrheum.150836. Publication link: e26345c8-1256-42a4-b6b1-0164320a7655 | PubMed:26879349
    • Yarwood, A., Eyre, S., & Worthington, J. (2016). Genetic susceptibility to rheumatoid arthritis and its implications for novel drug discovery.Expert Opinion on Drug Discovery, 11(8), 805-813. DOI: 10.1080/17460441.2016.1195366. Publication link: 896d6734-35b3-4f67-8f8d-2f9312d40543
    • Yarwood, A., Huizinga, T. W., & Worthington, J. (2016). The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA. Rheumatology (Print), 55(2), 199-209. . Publication link: 23aaec46-eac1-43a8-b2e1-c01bdac6760f
    • Yarwood, A., Viatte, S., Okada, Y., Plenge, R., Yamamoto, K., BRAGGSS, ... Eyre, S. (2016). Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: A Mendelian randomisation study.Annals of the Rheumatic Diseases, 75(1), 317-20. DOI: 10.1136/annrheumdis-2014-207210. Publication link: f39db358-92a0-480d-9c12-58d39222cb06

    Conference contribution

    • Jani, M., Dixon, W., Kearsley-Fleet, L., Bruce, I., Chinoy, H., Barton, A., ... Hyrich, K. (2016). Drug Specific Risk and Associated Factors for Vasculitis-like Events in Patients Exposed to TNFi Therapy: Results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis. In The Lancet. (Vol. 387, pp. S55). Publication link: d963f25f-871b-4e41-b9a7-02dd023b08b6

    Letter

  • 2015

    Article

    • Bluett, J., Riba Garcia, I., Hollywood, K., Verstappen, S. M. M., Barton, A., & Unwin, R. D. (2015). A HPLC-SRM-MS based method for the detection and quantification of methotrexate in urine at doses used in clinical practice for patients with rheumatological disease: a potential measure of adherence.The Analyst, 140(6). DOI: 10.1039/c4an02321h. Publication link: faa1abf9-bfb1-4714-b667-52f3b108d99b | PubMed:25671614
    • Bowes, J., Budu-Aggrey, A., Huffmeier, U., Uebe, S., Steel, K., Hebert, H., ... Barton, A. (2015). Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.Nature communications, 6, [6046]. DOI: 10.1038/ncomms7046. Publication link: 8d4d25cd-b041-48e4-80ce-80c9f7b88014 | PubMed:25651891
    • Bowes, J., Loehr, S., Budu-Aggrey, A., Uebe, S., Bruce, I. N., Feletar, M., ... Barton, A. (2015). PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus. Annals of the Rheumatic Diseases, 74(10), 1882-1885. DOI: 10.1136/annrheumdis-2014-207187. Publication link: 06c81937-c397-451d-929d-1b016af09453
    • Carmona, F. D., Mackie, S. L., Prieto-González, S., Solans, R., Ramentol-Sintas, M., González-Escribano, M. F., ... Martínez-Taboada, V. M. (2015). A Large-Scale Genetic Analysis Reveals a Strong Contribution of the HLA Class II Region to Giant Cell Arteritis Susceptibility.American Journal of Human Genetics, 96(4), 565-580. DOI: 10.1016/j.ajhg.2015.02.009. Publication link: e57a6c50-62e0-44ea-a4b5-99a95831ff81 | PubMed:25817017
    • Croteau-Chonka, D. C., Locke, A. E., Pers, T. H., Justice, A. E., Workalemahu, T., Wu, J. M. W., ... Boyd, H. A. (2015). New genetic loci link adipose and insulin biology to body fat distribution.Nature, 518(7538). DOI: 10.1038/nature14132. Publication link: 0bd01d9e-7409-482b-993a-f1a858c7e5ef | PubMed:25673412
    • Ding, J., Eyre, S., & Worthington, J. (2015). Genetics of RA susceptibility, what comes next?RMD Open, 1(1), [e000028]. DOI: 10.1136/rmdopen-2014-000028. Publication link: d7a01cec-490b-48f4-a4dd-38fc94686bfa
    • Diogo, D., Bastarache, L., Liao, K. P., Graham, R. R., Fulton, R. S., Greenberg, J. D., ... Plenge, R. M. (2015). TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits.PLoS ONE, 10(4), [ e0122271]. DOI: 10.1371/journal.pone.0122271. Publication link: 0b91b8ea-c1cf-4e28-b159-3884a141c19a | PubMed:25849893
    • Ermann, J., Rao, D. A., Teslovich, N. C., Brenner, M. B., & Raychaudhuri, S. (2015). Immune cell profiling to guide therapeutic decisions in rheumatic diseases.Nature reviews. Rheumatology, 11(9), 541-551. DOI: 10.1038/nrrheum.2015.71. Publication link: 873a48d4-4332-46c2-849d-1c210963e865 | PubMed:26034835
    • Finucane, H. K., Bulik-Sullivan, B., Gusev, A., Trynka, G., Reshef, Y., Loh, P-R., ... Price, A. L. (2015). Partitioning heritability by functional annotation using genome-wide association summary statistics.Nature Genetics, 47(11). DOI: 10.1038/ng.3404. Publication link: dc19544d-9496-4a4c-9473-4c07bdf65fb4 | PubMed:26414678
    • Fortune, M. D., Guo, H., Burren, O., Schofield, E., Walker, N. M., Ban, M., ... Wallace, C. (2015). Statistical Colocalization of Genetic Risk Variants for Related Autoimmune Diseases in the Context of Common Controls. Nature Genetics, 47(7). DOI: 10.1038/ng.3330. Publication link: 3e5ea8cd-8450-473c-9389-a82af82a85a3 | PubMed:26053495
    • Gutierrez-Achury, J., Zhernakova, A., Pulit, S. L., Trynka, G., Hunt, K. A., Romanos, J., ... de Bakker, P. I. W. (2015). Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.Nature Genetics, 47(6). DOI: 10.1038/ng.3268. Publication link: 6e65b440-a0ee-4a89-8178-37f23d55da8b | PubMed:25894500
    • Hayes, J. E., Trynka, G., Vijai, J., Offit, K., Raychaudhuri, S., & Klein, R. J. (2015). Tissue-Specific Enrichment of Lymphoma Risk Loci in Regulatory Elements.PLoS ONE, 10(9). DOI: 10.1371/journal.pone.0139360. Publication link: 4095ee59-a443-4d63-9cae-6ff73c527f43 | PubMed:26422229
    • Hébert, H. L., Bowes, J., Smith, R. L., Flynn, E., Parslew, R., Alsharqi, A., ... Warren, R. B. (2015). Identification of loci associated with late-onset psoriasis using dense genotyping of immune-related regions.The British journal of dermatology, 172(4), 933-939. DOI: 10.1111/bjd.13340. Publication link: fe1c9022-419a-4b31-adee-32058d445e7c | PubMed:25124732
    • Hu, X., Deutsch, A. J., Lenz, T. L., Onengut-Gumuscu, S., Han, B., Chen, W-M., ... Raychaudhuri, S. (2015). Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.Nature Genetics, 47(8). DOI: 10.1038/ng.3353. Publication link: 7dee6f01-78a4-4c06-b5a8-7045e37f8db4 | PubMed:26168013
    • Ibrahim, I., Humphreys, J., Mokhtar, I., Marshall, T., Verstappen, S., Symmons, D., ... Plant, D. (2015). Association of chemokine CXC ligand 12 gene polymorphism (rs1746048) with cardiovascular mortality in patients with rheumatoid arthritis: results from the Norfolk Arthritis Register. Annals of the Rheumatic Diseases, 74(11), 2099-2102. DOI: 10.1136/annrheumdis-2015-207851. Publication link: fb442f49-2db6-4048-9c62-487069f1827a
    • Jani, M., Barton, A., & Ho, P. (2015). Pharmacogenetics of treatment response in psoriatic arthritis. Current Rheumatology Reports (Online), 17(7), 518. DOI: 10.1007/s11926-015-0518-z. Publication link: 85fad2ef-25d3-4e3b-89f7-649186683510
    • Jani, M., Chinoy, H., Warren, R. B., Griffiths, C. E. M., Plant, D., Fu, B., ... BRAGGSS., . U. (2015). Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.Arthritis & rheumatology (Hoboken, N.J.), 67(8), 2011-2019. DOI: 10.1002/art.39169. Publication link: 52a86356-e59d-468a-ade9-1cef4a97948e | PubMed:26109489
    • Kavanagh, D., Yu, Y., Schramm, E. C., Triebwasser, M., Wagner, E., Raychaudhuri, S., ... Seddon, J. M. (2015). Rare Genetic Variants in the CFI Gene are Associated with Advanced Age-Related Macular Degeneration and Commonly Result in Reduced Serum Factor I Levels.Human molecular genetics, 24(13), 3861-70. DOI: 10.1093/hmg/ddv091. Publication link: bbc7bc60-dbaf-4889-bcf4-3f38ff4f605b | PubMed:25788521
    • Kearsley-Fleet, L., Hyrich, K. L., Davies, R., Lunt, M., & Southwood, T. R. (2015). Growth in children and adolescents with juvenile idiopathic arthritis over 2 years of treatment with etanercept: results from the British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study.Rheumatology (Oxford, England), 54(7), 1279-1285. DOI: 10.1093/rheumatology/keu489. Publication link: 2d573812-75f5-48ae-a137-828c205c128c | PubMed:25638806
    • Kearsley-Fleet, L., Závada, J., Hetland, M. L., Nordström, D. C., Aaltonen, K. J., Listing, J., ... Hyrich, K. L. (2015). The EULAR Study Group for Registers and Observational Drug Studies: comparability of the patient case mix in the European biologic disease modifying anti-rheumatic drug registers.Rheumatology (Oxford, England), 54(6), 1074-1079. DOI: 10.1093/rheumatology/keu446. Publication link: 0b0488bf-b14f-4508-95d5-3f365fa41829 | PubMed:25433042
    • Kim, K., Bang, S-Y., Lee, H-S., Cho, S-K., Choi, C-B., Sung, Y-K., ... Bae, S-C. (2015). High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.Annals of the rheumatic diseases, 74, e13. DOI: 10.1136/annrheumdis-2013-204749. Publication link: ef306f0d-2ac7-4209-a482-85b15f6040f1 | PubMed:24532676
    • Kim, K., Jiang, X., Cui, J., Lu, B., Costenbader, K. H., Sparks, J. A., ... Karlson, E. W. (2015). Interactions between amino-acid-defined MHC class II variants and smoking for seropositive rheumatoid arthritis.Arthritis & rheumatology (Hoboken, N.J.), 67(10), 2611-2623. DOI: 10.1002/art.39228. Publication link: b26d8a44-3b5e-41fe-a981-999dec839c9a | PubMed:26098791
    • Lee, S. H., Byrne, E. M., Hultman, C. M., Kähler, A., Vinkhuyzen, A. A., Ripke, S., ... van Riel, P. (2015). New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology, 44(5), 1706-1721. DOI: 10.1093/ije/dyv136. Publication link: 97b3871f-785e-4537-80a4-18330b1c8703 | PubMed:26286434
    • Lenz, T. L., Deutsch, A. J., Han, B., Hu, X., Okada, Y., Eyre, S., ... Raychaudhuri, S. (2015). Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.Nature Genetics, 47(9), 1085-1090. DOI: 10.1038/ng.3379. Publication link: 9a133c92-0710-42b6-b37b-68ecc036f7ed | PubMed:26258845
    • Locke, A. E., Kahali, B., Berndt, S. I., Justice, A. E., Pers, T. H., Day, F. R., ... Econs, M. J. (2015). Genetic studies of body mass index yield new insights for obesity biology.Nature, 518(7538). DOI: 10.1038/nature14177. Publication link: 0655fd50-d1d3-474b-b92d-e587f51cff70 | PubMed:25673413
    • Majeed, R., Baildam, E., Campbell, M., Chieng, A., Fallon, D., Hall, A., ... Swallow, V. (2015). Apps and Adolescents: A Systematic Review of Adolescents' Use of Mobile Phone and Tablet Apps That Support Personal Management of Their Chronic or Long-Term Physical Conditions.Journal of medical Internet research, 17(12), e287. DOI: 10.2196/jmir.5043. Publication link: ea90db13-774d-44d8-ae4d-d04c4204196b | PubMed:26701961
    • Martin, P., Mcgovern, A., Orozco, G., Duffus, K., Yarwood, A., Schoenfelder, S., ... Eyre, S. (2015). Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.Nature communications, 6, [10069]. DOI: 10.1038/ncomms10069. Publication link: 0d9a67a2-39d4-4fd1-a442-20b62d916fdf
    • McLaren, P. J., Coulonges, C., Bartha, I., Lenz, T. L., Deutsch, A. J., Bashirova, A., ... Fellay, J. (2015). Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load.Proceedings of the National Academy of Sciences of the United States of America, 112(47). DOI: 10.1073/pnas.1514867112. Publication link: af85e997-6ff8-43da-8327-fab49e1ab32b | PubMed:26553974
    • Montes, A., Perez-Pampin, E., Narváez, J., Cañete, J. D., Marquez, A., Pascual-Salcedo, D., ... Del Carmen Ordóñez, M. (2015). Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study.Arthritis research & therapy, 17(1). DOI: 10.1186/s13075-015-0571-z. Publication link: c419150b-e329-41ee-a417-b568639e95da | PubMed:25885039
    • Ochoa, E., Martin, J-E., Assasi, S., Beretta, L., Carreira, P., Guillén, A., ... The Spanish Scleroderma Group, A. (2015). Confirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis.Clinical and Experimental Rheumatology, 33 (4 (Suppl 91)), [e87645]. . Publication link: 6abce57e-acda-4eea-b195-629b8db8070b | PubMed:26314374
    • Oksenberg, J. R., Thomsen, I., Leslie, S., International_Inflammatory_Bowel_Disease_Genetics_Consortium, . U., Australia_and_New_Zealand_IBDGC, . U., Belgium_IBD_Genetics_Consortium, . U., ... Zhao, Z. Z. (2015). High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.Nature Genetics, 47(2). DOI: 10.1038/ng.3176. Publication link: 210c4716-9ecd-4e3e-ad20-fe41172a6f9d | PubMed:25559196
    • Oliver, J., Plant, D., Webster, A. P., & Barton, A. (2015). Genetic and genomic markers of anti-TNF treatment response in rheumatoid arthritis.Biomarkers in Medicine, 9(6). DOI: 10.2217/bmm.15.18. Publication link: 8c2af58a-0109-499a-8604-c06e218ad171 | PubMed:26079957
    • Ombrello, M. J., Remmers, E. F., Tachmazidou, I., Grom, A., Foell, D., Haas, J-P., ... Wood, P. (2015). HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.Proceedings of the National Academy of Sciences of the United States of America, 112 (52), 15970-15975. DOI: 10.1073/pnas.1520779112. Publication link: 3c2e2540-0cf8-4275-a590-693aec444069 | PubMed:26598658
    • Pers, T. H., Karjalainen, J. M., Chan, Y., Westra, H-J., Wood, A. R., Yang, J., ... Franke, L. (2015). Biological interpretation of genome-wide association studies using predicted gene functions.Nature communications, 6. DOI: 10.1038/ncomms6890. Publication link: 7917b26d-7716-4de8-9fa1-4ca5633d6428 | PubMed:25597830
    • Schuetz, P., Leuppi, J. D., Bingisser, R., Bodmer, M., Briel, M., Drescher, T., ... Rutishauser, J. (2015). Prospective analysis of adrenal function in patients with acute exacerbations of COPD: The REDUCE* trial (*Reduction in the Use of Corticosteroids in Exacerbated COPD).European journal of endocrinology / European Federation of Endocrine Societies. DOI: 10.1530/EJE-15-0182. Publication link: 3668ecdc-bdf4-43f7-9333-f8526e67cd5e | PubMed:25855628
    • Scott, I. C., Rijsdijk, F., Walker, J., Quist, J., Spain, S. L., Tan, R., ... Lewis, C. M. (2015). Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?The Journal of rheumatology, 42(7). DOI: 10.3899/jrheum.141211. Publication link: 377ddd6b-ce18-4002-af6b-3fcd5094c325 | PubMed:25979711
    • Smith, S. L., Eyre, S., Yarwood, A., Hyrich, K. L., Morgan, A. W., Wilson, A. G., ... Barton, A. (2015). Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples. Arthritis Research & Therapy (Print), 17, 359. DOI: 10.1186/s13075-015-0868-y. Publication link: 4c8f3f0a-e9a3-4787-8412-0ba442d571f0
    • Sul, J. H., Raj, T., de Jong, S., de Bakker, P. I. W., Raychaudhuri, S., Ophoff, R. A., ... Han, B. (2015). Accurate and Fast Multiple-Testing Correction in eQTL Studies.American Journal of Human Genetics, 96(6). DOI: 10.1016/j.ajhg.2015.04.012. Publication link: 92e89bf3-88a1-4f0e-9073-946a5a0fadd3 | PubMed:26027500
    • The Network and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium (2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.Nature neuroscience, 18(2). DOI: 10.1038/nn.3922. Publication link: 3a93eb81-a7c0-445e-97b2-9dbf8045bc35 | PubMed:25599223
    • Trynka, G., Westra, H-J., Slowikowski, K., Hu, X., Xu, H., Stranger, B. E., ... Raychaudhuri, S. (2015). Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci.American Journal of Human Genetics, 97(1). DOI: 10.1016/j.ajhg.2015.05.016. Publication link: 6fc8386e-b9af-40ce-bbe6-c93ae5c4b866 | PubMed:26140449
    • vanSteenbergen, H. W., Raychaudhuri, S., Rodríguez-Rodríguez, L., Rantapää-Dahlqvist, S., Berglin, E., Toes, R. E. M., ... vanderHelm-vanMil, A. H. M. (2015). Valine and Leucine at HLA-DRβ1 position 11 associate with radiographic progression in rheumatoid arthritis, independent of the Shared Epitope alleles but not independent of anti-citrullinated peptide antibodies.Arthritis & rheumatology (Hoboken, N.J.), 67(4), 877-886. DOI: 10.1002/art.39018. Publication link: b7d23dbd-8612-426a-a436-4b11148fefea | PubMed:25580908
    • Viatte, S., Plant, D., Han, B., Fu, B., Yarwood, A., Thomson, W., ... Barton, A. (2015). Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.JAMA, 313(16), 1645-1656. DOI: 10.1001/jama.2015.3435. Publication link: b882366e-0899-4461-9fbe-e64430a95f28 | PubMed:25919528
    • Yarwood, A., Han, B., Raychaudhuri, S., Bowes, J., Lunt, M., Pappas, D. A., ... Eyre, S. (2015). A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk. Annals of the Rheumatic Diseases, 74(1), 170-176. DOI: 10.1136/annrheumdis-2013-204133. Publication link: e1cf45d5-af36-4757-afbd-7b1cbd3cde8d | PubMed:24092415
  • 2014

    Article

    • Arking, D. E., Pulit, S. L., Crotti, L., Van Der Harst, P., Munroe, P. B., Koopmann, T. T., ... Newton-Cheh, C. (2014). Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nature Genetics, 46(8), 826-836. DOI: 10.1038/ng.3014. Publication link: 0ff8f6ad-22c2-4a36-9767-5cf91d769f12 | PubMed:24952745
    • Banka, S., Cain, S. A., Carim, S., Daly, S. B., Urquhart, J. E., Erdem, G., ... Newman, W. G. (2014). Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis. Annals of the Rheumatic Diseases, 74(6). DOI: 10.1136/annrheumdis-2013-204309. Publication link: dbf7c90f-fb4d-4e41-84ca-f95fb7b6c479 | PubMed:24442880
    • Bluett, J., Ibrahim, I., Plant, D., Hyrich, K. L., Bruce, I., Kitas, G., ... Barton, A. (2014). Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: Results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Pharmacogenomics Journal, 14(2), 171-175. DOI: 10.1038/tpj.2013.26. Publication link: a199e365-9e83-4464-bd9d-c2458feebf4d | PubMed:23856853
    • Bluett, J., Morgan, C., Thurston, L., Plant, D., Hyrich, K. L., Morgan, A. W., ... BRAGGSS (2014). Impact of Inadequate Adherence on response to subcutaneously administered anti-TNF drugs: Results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Rheumatology (Print), 54(3), 494-499. DOI: 10.1093/rheumatology/keu358. Publication link: 31cc6859-5bff-4ac4-9f8f-b6dd01fbca69 | PubMed:25213131
    • Brownstein, C. A., Beggs, A. H., Homer, N., Merriman, B., Yu, T. W., Flannery, K. C., ... Margulies, D. M. (2014). An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.Genome biology, 15(3). DOI: 10.1186/gb-2014-15-3-r53. Publication link: 18a60470-71bb-4491-bd15-1b087a80c700 | PubMed:24667040
    • Castelino, M., Eyre, S., Upton, M., Ho, P., & Barton, A. (2014). The bacterial skin microbiome in psoriatic arthritis, an unexplored link in pathogenesis: Challenges and opportunities offered by recent technological advances. Rheumatology, 53(5), 777-784. [ket319]. DOI: 10.1093/rheumatology/ket319. Publication link: 885146b9-82ba-452a-a35b-664d9cf388e2 | PubMed:24067887
    • Cobb, J. E., Hinks, A., & Thomson, W. (2014). The genetics of juvenile idiopathic arthritis: Current understanding and future prospects. Rheumatology, 53(4), 592-599. [ket314]. DOI: 10.1093/rheumatology/ket314. Publication link: d971787d-5086-4f23-8a54-4e5584c1c8bf | PubMed:24049100
    • Cobb, J., Cule, E., Moncrieffe, H., Hinks, A., Ursu, S., Patrick, F., ... Thomson, W. (2014). Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.The pharmacogenomics journal, 14(4), 356-364. DOI: 10.1038/tpj.2014.3. Publication link: 4d42478e-41a0-4ffd-aedf-b74a8b8300ae | PubMed:24709693
    • Cordingley, L., Prajapati, R., Plant, D., Maskell, D., Morgan, C., Ali, F. R., ... Barton, A. (2014). Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis. Arthritis Care & Research, 66(6), 861-868. DOI: 10.1002/acr.22249. Publication link: c07b3a3d-98ac-4892-814c-5b7ca9e1024e | PubMed:24339425
    • Dunstan, S. J., Hue, N. T., Han, B., Li, Z., Tram, T. T. B., Sim, K. S., ... Khor, C. C. (2014). Variation at HLA-DRB1 is associated with resistance to enteric fever.Nature Genetics, 46(12), 1333-1336. DOI: 10.1038/ng.3143. Publication link: 0836a084-5e25-450f-9240-f9b83ab07988 | PubMed:25383971
    • Eyre, S., & Worthington, J. (2014). Take your PICS: moving from GWAS to immune function. Immunity, 41(6), 883-5. DOI: 10.1016/j.immuni.2014.12.014. Publication link: f3bf3e41-cb71-432e-a5a1-6def9e9f6bcf | PubMed:25526303
    • Gavan, S., Harrison, M., Iglesias, C., Barton, A., Manca, A., & Payne, K. (2014). Economics of stratified medicine in rheumatoid arthritis.Current Rheumatology Reports, 16(12), 1-11. [468]. DOI: 10.1007/s11926-014-0468-x. Publication link: cf51d020-00e9-4515-951a-3400d04d2bbe | PubMed:25366935
    • Gusev, A., Trynka, G., Finucane, H., Vilhjálmsson, B. J., Xu, H., Zang, C., ... McCarroll, S. (2014). Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases.American Journal of Human Genetics, 95(5), 535–552. DOI: 10.1016/j.ajhg.2014.10.004. Publication link: 0705e946-f876-461a-a269-e25eb519cc5c | PubMed:25439723
    • Han, B., Diogo, D., Eyre, S., Kallberg, H., Zhernakova, A., Bowes, J., ... Raychaudhuri, S. (2014). Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity. American Journal of Human Genetics, 94(4), 522-532. DOI: 10.1016/j.ajhg.2014.02.013. Publication link: 950c3e9c-9f4b-44d6-a3ef-daca8c586d19 | PubMed:24656864
    • Hébert, H. L., Bowes, J., Smith, R. L., McHugh, N. J., Barker, J. N. W. N., Griffiths, C. E. M., ... Warren, R. B. (2014). Polymorphisms in IL-1B distinguish between psoriasis of early and late onset. Journal of Investigative Dermatology, 134(5), 1459-1462. DOI: 10.1038/jid.2013.485. Publication link: 30edd265-ec8e-4246-9a1a-b9df9035f039 | PubMed:24217014
    • Hu, X., Kim, H., Raj, T., Brennan, P. J., Trynka, G., Teslovich, N., ... Raychaudhuri, S. (2014). Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells. PLoS Genetics, 10(6), [e1004404]. DOI: 10.1371/journal.pgen.1004404. Publication link: 395bc167-ffbb-42d1-b96b-e35f2b3a0340 | PubMed:24968232
    • Jani, M., Barton, A., Warren, R. B., Griffiths, C. E. M., & Chinoy, H. (2014). The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases. Rheumatology, 53(2), 213-222. [ket260]. DOI: 10.1093/rheumatology/ket260. Publication link: 7e327757-a794-4b41-a00d-d45a8e620262 | PubMed:23946436
    • Lee, M. N., Ye, C., Villani, A. C., Raj, T., Li, W., Eisenhaure, T. M., ... Hacohen, N. (2014). Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science, 343(6175), [1246980]. DOI: 10.1126/science.1246980. Publication link: 0cc93e47-cbf7-411a-a7e9-156ba5758fdb | PubMed:24604203
    • Liao, K. P., Diogo, D., Cui, J., Cai, T., Okada, Y., Gainer, V. S., ... Plenge, R. M. (2014). Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls. Annals of the Rheumatic Diseases, 73(6), 1170-1175. DOI: 10.1136/annrheumdis-2012-203202. Publication link: 23b6a605-bb70-407f-9ed0-86e371273973 | PubMed:23716066
    • Lim, E. T., Liu, Y. P., Chan, Y., Tiinamaija, T., Käräjämäki, A., Madsen, E., ... Daly, M. J. (2014). A Novel Test for Recessive Contributions to Complex Diseases Implicates Bardet-Biedl Syndrome Gene BBS10 in Idiopathic Type 2 Diabetes and Obesity.American Journal of Human Genetics, 95(5). DOI: 10.1016/j.ajhg.2014.09.015. Publication link: adacf039-d0c4-4e3a-8867-f07d894be56c | PubMed:25439097
    • López-Isac, E., Bossini-Castillo, L., GGuerra, S., Assassi, S., Zhou, X., PilarSimeón, C., ... Martin, J. (2014). Identification of IL12RB1 as a novel systemic sclerosis susceptibility locus.Arthritis & rheumatology (Hoboken, N.J.), 66(12), 3521-3523. DOI: 10.1002/art.38870. Publication link: 3035410c-f47c-420d-bbff-bf77c57e61f5 | PubMed:25199642
    • López-Isac, E., Bossini-Castillo, L., Simeon, C. P., Egurbide, M. V., Alegre-Sancho, J. J., Callejas, J. L., ... Oreiro, N. (2014). A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility. Arthritis Research and Therapy, 16(1), [R6]. DOI: 10.1186/ar4432. Publication link: 440c5dcf-331d-415b-b8c9-5a2f31d5057e | PubMed:24401602
    • Mahajan, A., Go, M. J., Zhang, W., Below, J. E., Gaulton, K. J., Ferreira, T., ... Morris, A. P. (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics, 46(3), 234-244. DOI: 10.1038/ng.2897. Publication link: 89f6f052-f493-45d8-9714-aa6887b4933a | PubMed:24509480
    • Massey, J., & Eyre, S. (2014). Rare variants and autoimmune disease.Briefings in functional genomics, 13(5). DOI: 10.1093/bfgp/elu011. Publication link: 6b923fff-65fb-48cb-834f-e53758f6950f | PubMed:24817515
    • Mathews, R. J., Robinson, J. I., Battellino, M., Wong, C., Taylor, J. C., Eyre, S., ... McDermott, M. F. (2014). Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); Genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment. Annals of the Rheumatic Diseases, 73(6), 1202-1210. DOI: 10.1136/annrheumdis-2013-203276. Publication link: 2273bbf9-e8e7-41bd-a301-1d83481137a8 | PubMed:23687262
    • Mayes, M. D., Bossini-Castillo, L., Gorlova, O., Martin, J. E., Zhou, X., Chen, W. V., ... Martin, J. (2014). Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. American Journal of Human Genetics, 94(1), 47-61. DOI: 10.1016/j.ajhg.2013.12.002. Publication link: 02b9e4ce-0571-41ec-b2ba-8b9c7ecf8498 | PubMed:24387989
    • Nogueira, L., Cornillet, M., Singwe-Ngandeu, M., Viatte, S., Bas, S., Gabay, C., & Serre, G. (2014). In Black Africans with rheumatoid arthritis, ACPA recognize citrullinated fibrinogen and the derived peptides α36-50Cit38,42 and β60-74Cit60,72,74, like in Caucasians. Clinical Immunology, 152(1-2), 58-64. DOI: 10.1016/j.clim.2014.02.011. Publication link: b9f462b1-ad13-483c-a3f9-b522008840eb | PubMed:24589748
    • Okada, Y., Diogo, D., Greenberg, J. D., Mouassess, F., Achkar, W. A. L., Fulton, R. S., ... Plenge, R. M. (2014). Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene. PLoS ONE, 9(2), [e87645]. DOI: 10.1371/journal.pone.0087645. Publication link: e3cda1cf-5524-43f1-9074-fba02c7933ee | PubMed:24520335
    • Okada, Y., Kim, K., Han, B., Pillai, N. E., Ong, R. T-H., Saw, W-Y., ... Raychaudhuri, S. (2014). Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations.Human molecular genetics, 23(25), 6916-6926. DOI: 10.1093/hmg/ddu387. Publication link: ce37373c-d593-41ea-8959-0b4f1c163a15 | PubMed:25070946
    • Okada, Y., Wu, D., Trynka, G., Raj, T., Terao, C., Ikari, K., ... Plenge, R. M. (2014). Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature, 506(7488), 376-381. DOI: 10.1038/nature12873. Publication link: 0a9cff07-42ec-43a7-b131-161624b9538b | PubMed:24390342
    • Orozco, G., Viatte, S., Bowes, J., Martin, P., Wilson, A. G., Morgan, A. W., ... Eyre, S. (2014). Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. Arthritis and Rheumatology, 66(1), 24-30. DOI: 10.1002/art.38196. Publication link: 5965ac24-2933-4c73-982f-e5eadf9525a3 | PubMed:24114500
    • Pillai, N. E., Okada, Y., Saw, W. Y., Ong, R. T. H., Wang, X., Tantoso, E., ... Teo, Y. Y. (2014). Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations. Human Molecular Genetics, 23(16), 4443-4451. [ddu149]. DOI: 10.1093/hmg/ddu149. Publication link: 3f126b81-b2a8-4e16-a35e-93249c2c8117 | PubMed:24698974
    • Plant, D., Wilson, A. G., & Barton, A. (2014). Genetic and epigenetic predictors of responsiveness to treatment in RA. Nature Reviews Rheumatology, 10(6), 329-337. DOI: 10.1038/nrrheum.2014.16. Publication link: 4b588e02-32d8-4ffc-8350-4c75e1eaad14 | PubMed:24535543
    • Raj, T., Rothamel, K., Mostafavi, S., Ye, C., Lee, M. N., Replogle, J. M., ... De Jager, P. L. (2014). Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science, 344(6183), 519-523. DOI: 10.1126/science.1249547. Publication link: 42ac602d-3b88-4e7b-839f-07e7aed83483 | PubMed:24786080
    • Raychaudhuri, S., Claussnitzer, M., Dankel, S. N., Klocke, B., Grallert, H., Glunk, V., ... Laumen, H. (2014). Leveraging cross-species transcription factor binding site patterns: From diabetes risk loci to disease mechanisms. Cell, 156(1-2), 343-358. DOI: 10.1016/j.cell.2013.10.058. Publication link: c08cade5-1bdc-4c5c-80a2-dec7bd0441a8 | PubMed:24439387
    • Raychaudhuri, S., Hara, K., Fujita, H., Johnson, T. A., Yamauchi, T., Yasuda, K., ... Kadowaki, T. (2014). Genome-wide association study identifies three novel loci for type 2 diabetes. Human Molecular Genetics, 23(1), 239-246. [ddt399]. DOI: 10.1093/hmg/ddt399. Publication link: f759a4a7-c8ff-4f13-a966-94799d6c08f1 | PubMed:23945395
    • Roussos, P., Mitchell, A. C., Voloudakis, G., Fullard, J. F., Pothula, V. M., Tsang, J., ... Sklar, P. (2014). A role for noncoding variation in schizophrenia.Cell Reports, 9(4), 1417-1429. DOI: 10.1016/j.celrep.2014.10.015. Publication link: 5619eb69-52ee-4a14-b0b5-319a4df17700 | PubMed:25453756
    • Schramm, E. C., Clark, S. J., Triebwasser, M. P., Raychaudhuri, S., Seddon, J. M., & Atkinson, J. P. (2014). Genetic variants in the complement system predisposing to age-related macular degeneration: A review. Molecular Immunology, 61(2), 118-125. DOI: 10.1016/j.molimm.2014.06.032. Publication link: cf00081a-b009-4bad-af2a-c74faa5aab26 | PubMed:25034031
    • Silva-Fernandez, L., & Hyrich, K. (2014). Rheumatoid arthritis: When TNF inhibitors fail in RA - Weighing up the options. Nature Reviews Rheumatology, 10(5), 262-264. DOI: 10.1038/nrrheum.2014.34. Publication link: 5e716621-9eb5-4efb-92c9-99d4a91b8e7a | PubMed:24614594
    • Slowikowski, K., Hu, X., & Raychaudhuri, S. (2014). SNPsea: An algorithm to identify cell types, tissues and pathways affected by risk loci. Bioinformatics, 30(17), 2496-2497. DOI: 10.1093/bioinformatics/btu326. Publication link: 86f45bca-af6e-48f0-a64f-8016301123c8 | PubMed:24813542
    • Viatte, S., Yarwood, A., McAllister, K., Al-Mudhaffer, S., Fu, B., Flynn, E., ... Duffus, K. (2014). The role of genetic polymorphisms regulating vitamin D levels in rheumatoid arthritis outcome: A Mendelian randomisation approach. Annals of the Rheumatic Diseases, 73(7), 1430-1433. DOI: 10.1136/annrheumdis-2013-204972. Publication link: baeae829-7410-464d-80c6-0762bb078036 | PubMed:24651622
    • Yu, Y., Triebwasser, M. P., Wong, E. K. S., Schramm, E. C., Thomas, B., Reynolds, R., ... Seddon, J. M. (2014). Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration.Human molecular genetics, 23(19), 5283-5293. DOI: 10.1093/hmg/ddu226. Publication link: 2dc2aa37-ebd1-4c61-b6dc-e7fb1e6f263b | PubMed:24847005
    • Závada, J., Lunt, M., Davies, R., Low, A. S. L., Mercer, L. K., Galloway, J. B., ... Hyrich, K. L. (2014). The risk of gastrointestinal perforations in patients with rheumatoid arthritis treated with anti-TNF therapy: Results from the BSRBR-RA. Annals of the Rheumatic Diseases, 73(1), 252-255. DOI: 10.1136/annrheumdis-2012-203102. Publication link: e90e29f5-e5cb-4d94-a39b-6e440955fee4 | PubMed:23644671

    Letter

    • Duffus, K., Ibrahim, I., McAllister, K., Plant, D., Symmons, D., Marshall, T., ... Eyre, S. (2014). Investigation of an interleukin-6 receptor gene polymorphism (rs2228145) as a predictor of cardiovascular mortality in inflammatory polyarthritis: Results from the Norfolk Arthritis Register. Annals of the Rheumatic Diseases, 73(4), 787-788. DOI: 10.1136/annrheumdis-2013-204330. Publication link: 965a5b74-0ccf-49bf-8acb-adb57d4d382e
    • Yarwood, A., Viatte, S., Plant, D., Morgan, A. W., Isaacs, J., Wilson, A. G., ... Barton, A. (2014). Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: A Mendelian randomisation approach. Annals of the Rheumatic Diseases, 73(5), 938-940. DOI: 10.1136/annrheumdis-2013-204443. Publication link: b9655eac-b757-4f30-93a2-677429d9aa74 | PubMed:24323394