Arthritis Research UK Centre for Genetics and Genomics

Director: Professor Jane Worthington, Deputy Director: Professor Wendy Thomson

The Arthritis Research UK Centre for Genetics and Genomics undertakes a major research programme focussing on the identification and characterisation of genetic variants that influence susceptibility to and outcome of arthritic diseases including rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis.

All the diseases investigated are complex conditions for which susceptibility is determined by a combination of genetic and environmental or lifestyle factors. Genetic and genomic factors are also known to affect how the disease progresses and influence response to treatment (outcome) over time.

To date, much of research has been aimed at identifying genetic risk factors and although considerable progress has been made we now face the challenge of investigating the identified loci in detail. Our Functional Genomics programme of work aims to determine how subtle changes in the genetic code result in altered function or level of production of proteins and how in turn this influences the disease process.

To find out more detail about the studies we are carrying out in each of the diseases listed and in Functional Genomics, please click the links below.

Rheumatoid arthritis  (RA)

Psoriatic arthritis (PsA)

Juvenile idiopathic arthritis (JIA)

Functional Genomics